Iodine Software Launches Next-Generation Pre-Bill Solution to Help Health Systems Right-Size Reimbursement
New capabilities pinpoint revenue leakage post-discharge, driving measurable financial performance
AUSTIN, Tex. – May 15, 2025 – Iodine Software, the leader in healthcare AI for revenue cycle optimization, today launched the next generation of its pre-bill solution, AwarePre-Bill, designed to help health systems close critical revenue gaps before claims are submitted. Built on years of proven success, the solution enables health systems to conduct financially targeted retrospective reviews, improving code accuracy and documentation to help right-size reimbursement. With Iodine, clients have captured $3–4 million per month in previously missed revenue.
The launch comes at a time when health systems are under immense financial pressure. Claims denials have risen 16% over the past six years, and nearly 40% of hospitals operate at a deficit. Although more than 80% of appealed denials are ultimately overturned, limited resources prevent many systems from pursuing them—leaving millions in revenue on the table. Increasingly, hospitals are turning to AI-driven solutions like Iodine’s to address these gaps and ensure financial sustainability in an increasingly complex payer environment.
“Iodine’s pre-bill technology has delivered measurable ROI for AdventHealth,” said Dr. Christopher Riccard, VP of Hospital Medicine and CDI at AdventHealth. “We’ve seen a meaningful lift in high-impact queries that drive both revenue and quality outcomes. The ability to prioritize the right cases—not just more—has transformed our teams’ productivity and strengthened our financial performance.”
The solution leverages proven AI to pinpoint patient records with the greatest financial impact, exclude low-value cases, and validate DRG and ICD-10 codes by identifying missing documentation, recommending more appropriate codes, and surfacing alternative principal diagnoses. It also identifies post-discharge query opportunities, flags diagnoses lacking sufficient physician support, and detects financially significant quality events—such as HACs and PSIs—that may warrant documentation or coding updates. Each recommendation is backed by relevant clinical context, enabling reviewers to act with speed, accuracy, and confidence.
Recognizing the persistent staffing challenges facing health systems, Iodine will also offer tech-enabled services to help close pre-bill revenue gaps.
“Hospitals are navigating rising denial rates and shrinking margins,” said William Chan, CEO of Iodine Software. “We remain focused on our mission to be a true partner in helping health systems get reimbursed accurately for the care they provide. With enhanced pre-bill capabilities and flexible, outcomes-based pricing and service models, we are making it easier for healthcare leaders to adopt the tools they need to safeguard financial performance and support long-term stability.”
Today, hundreds of health systems rely on Iodine to improve cycle revenue performance—reducing review times by 63% and generating millions in incremental impact annually. As Chan notes, “In an environment where every dollar counts, we’re delivering the tools hospitals need to protect their margins—and their mission.”
For more information on Iodine Software and its industry-leading AI solutions, visit www.iodinesoftware.com.
About AdventHealth
AdventHealth is a connected network of care that helps people feel whole – body, mind and spirit. More than 100,000 team members across a national footprint provide whole-person care to nearly nine million people annually through more than 2,000 care sites that include hospitals, physician practices, ambulatory surgery centers, outpatient clinics, home health agencies, hospice centers, the AdventHealth app and more. Our wholistic approach to improving the health and prosperity of our communities is inspired by our mission to extend the healing ministry of Christ.
About Iodine Software
Iodine Software is the leader in AI-powered clinical intelligence, helping healthcare organizations capture the full value of patient care. Our solutions drive accurate documentation, optimize reimbursement, reduce administrative burden, and help prevent costly denials—powering more efficient revenue cycle operations. For over a decade, health systems have trusted Iodine to apply the right AI—whether machine learning, deep learning, GenAI and Agentic AI— to the right use case, consistently delivering reliable, high-impact outcomes.
Iodine’s proprietary Clinical Intelligence Engine, CognitiveML, mirrors clinical judgment and draws insights from one of the largest sets of inpatient clinical data in the country. The platform continuously reviews every patient chart to deliver the most holistic, real-time clinical snapshot available. Recognized as Best in KLAS, Iodine’s Clinical Intelligence Suite scales clinical intelligence through solutions like AwareCDI, AwareUM, and AwarePre-Bill, helping healthcare organizations achieve financial returns and improve quality. Learn more at www.iodinesoftware.com.